The 5 most shocking results in NCAA March Madness opening weekend history

16^th seed Fairleigh Dickinson shocked the basketball world last week, beating number one seed Purdue in the first round of March Madness.

The opening round of March Madness is prime time for upsets in the competition, with FDU becoming the second team in the tournament's history to beat a first seed as the 16^th seed.

After FDU's magical weekend, let's look at the five most shocking upsets in March Madness history.

15 seed Saint Peter's defeated two-seed Kentucky in the opening weekend of the 2022 March Madness, creating more heartache for 'The Wildcats,' who hadn't won a game in the tournament since 2019.

Guards Daryl Banks 111 and Doug Edert combined for 47 points in the game, marking a career-high for Banks in the memorable victory.

The victory for Saint Peter's was their first-ever win at the NCAA March Madness event. The school is small, with just 3500 students attending the college in Jersey City.

Middle Tennessee State became the eighth team number 15^th seed to upset a number two seed at March Madness, toppling Michigan State 90-81 in the opening round of the 2016 tournament.

Middle Tennessee players Reggie Upshaw and Giddy Potts combined for 40 points in the victory, helping complete this incredible feat for the first time since 2013.

According to espn.com, Giddy Potts said, "We wanted to win this game as bad as anybody wanted us to win. We played our (butts) off today."

Duke had a roster of eight future NBA players, led by Mason Plumlee, Austin Rivers, and the infamous coach Mike Krzyzewski. However, it wasn't enough to beat 15^th seed Lehigh in 2012, who NBA star CJ McCollum led.

The future NBA star showed his class in the game, showcasing the talent the NBA would come to love in the future, dropping 30 points on Duke, helping his side win 75-70.

According to espn.com, Coach K said, "Tonight's one of those lows. But it wasn't just our doing. They played that well. They played that well. And again, my hat's off to them."

The second most shocking upset was the second time a number 16 seed defeated a number one seed team after FDU defeated Purdue 63-58 last week.

FDU is only in March Madness on a technicality, losing to Merrimack in the NEC tournament title game. Still, Merrimack was ineligible because they hadn't fully transitioned into an NCAA Division One school.

After bringing in former D2 coach Tobin Anderson, the progression has been monumental, going from a 4-22 season last year to beating the number one seed at March Madness by points spread of 23.5. The largest upset by points spread since 1985.

The University of Maryland-Baltimore County shocked the sporting world, becoming the first 16^th seed to defeat a first seed in March Madness history.

If a 16^th seed beating a first seed wasn't shocking enough, the manner of the victory left the basketball world speechless, with UMBC beating Virginia by 20 points (74-54).

UMBC was led by Jairus Lyles, who dropped 28 points in the game. UMBC scored 53 second-half points, one point shy of the number-one seed's entire total for the game.